Consultant of ophthalmology cairo university retinal ganglion cells encompass three layers in the retina. Comparative study of macular ganglion cellinner plexiform layer. Ganglion cell complex analysis provides a more comprehensive picture of disease status. Relation between macular retinal ganglion cellinner plexiform. A metaanalysis looking at different oct instruments and differing gcc. The thicknesses of the ganglion cell complex and most of the peripapillary retinal nerve fibre layer were correlated with refraction and axial length.
Schuman, md, 2hiroshi ishikawa, md, gadi wollstein, md,2 rohit varma, md, mph, 1david huang, md, phd purpose. Utility of ganglion cell complex analysis in early. To determine the importance of ganglion cell complex gcc analysis as a parameter for early diagnosis of glaucoma and for following glaucoma progression and to compare glaucoma progression with conventional visual field analysis using a different type of spectraldomain optical coherence tomography sdoct. Relative diagnostic odds ratio for ganglion cell complex and ganglion cell inner. Macular retinal ganglion cell complex thickness and its. However, retinal ganglion cells are large and complex cells extending. Description medications like plaquenil and chloroquine can induce degenerative changes in the ganglion cells and photoreceptor cells of the retina. The optic nerve head analysis report consists of a b scan image of the optic. Macular ganglion cell layer thickness shows a topographic hemiatrophy in retrochiasmal lesions, which manifests.
There are a number of ways to assess the ganglion cell complex gcc thickness metric available on sdoct devices. The future of oct a significant challenge with oct technology is keeping up with advances without losing previous data during system and software upgrades. Macular ganglion cell analysis gca of the cirrus hdoct in glaucoma the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. The ganglion cell complex gcc is defined as the three innermost retinal layers. Here youll find current best sellers in books, new releases in books, deals in books, kindle ebooks, audible audiobooks, and so much more. The system offers motion correction technology mct, 2phase noise reduction, realtime tracking and deep choroidal imaging, as standard. Ng, 1,2 preetigupta, 1,2 yihchungtham, 1,2 chyefongpeck, 1 tienyinwong, 1,2,3 mohammadkamranikram, 1,3 andcaroly. Repeatability of perimacular ganglion cell complex analysis with spectraldomain optical coherence tomography dorothy s. Neither is a pure ganglion cell layer analysis, how. Peripapillary and macular retinoschisis in a patient with. In comparative analysis, the association between the central cluster ms and average gcipl. The macular ganglion cell complex gcc, available in commercial fourierdomain optical coherence tomography, allows the quantification of the innermost retinal layers that are potentially involved in the glaucomatous damage, including the retinal nerve fiber rnfl, ganglion cell and inner plexiform layers.
The power of focal loss volume flv% and global loss. Pseudoexfoliation material was noted on the iris and the lens capsule. Ganglion cells peak density ranges between 31,600 and 37,800 cells mm, 2 and the highest cells density in a horizontally oriented elliptical ring of 0. Detection of macular ganglion cell loss in glaucoma by fourierdomain optical coherence tomography ou tan, phd, 1vikas chopra, md, ake tzuhui lu, phd,1 joel s. Author links open overlay panel divakar gupta sanjay asrani. The books homepage helps you explore earths biggest bookstore without ever leaving the comfort of your couch.
To map ganglion cell complex gcc thickness with highspeed fourierdomain optical coherence. The use of oct ganglion cell complex analysis may be a more effective way to detect compressive chiasmopathy or optic neuropathy early on, according to. Gcc analysis may offer the opportunity to detect early signs of ganglion cell death associated with glaucoma, retina or neurological diseases. Evaluation of macular ganglion cell analysis compared to retinal. Ganglion cells are the projection neurons of the vertebrate retina, conveying information from other retinal neurons to the rest of the brain. Research article repeatability of perimacular ganglion. This exits the eye at the back of the retina which is where there are no rods and cones hence why we have blind spots. Ganglion cell complex gcc analysis ganglion cell complex gcc is the natural process of the ganglion cell death, prior to the loss of retinal nerve fibres. Detection of macular ganglion cell loss in glaucoma by. Search the worlds most comprehensive index of fulltext books. To evaluate the relationship between the macular ganglion cell complex mgcc thickness, which is the sum of the retinal nerve fiber, ganglion cell, and inner plexiform layers, measured with a spectraldomain optical coherence tomograph and the optic nerve head topography measured with a confocal scanning laser ophthalmoscope in glaucomatous eyes with visual field defects localized.
Therefore, when using these for clinical purposes, attention must be paid to the refractive state of the patient. The macular ganglion cell complex gcc, available in commercial fourierdomain optical coherence tomography, allows the quantification of. The macular ganglion cell complex gcc, available in commercial fourier domain optical coherence tomography, allows the quantification of. Optical coherence tomography retinal ganglion cell complex analysis for the detection of early chiasmal compression richard j. Figures ak are comparisons of rnfl thickness analysis, macular thickness analysis and ganglion cell complex analysis as represented by each model. The analysis of the ganglion cell complex is a measure of thinning of the inner retinal layersthe neurological representation of the retina.
Ganglion cell analysis advanced rpe analysis existing cirrus cube data carl zeiss meditec, inc cirrus 6. Role of ganglion cell complex gcc in evaluation of glaucoma by azza ismaiel sedkey, m. Full text ganglion cell complex analysis in glaucoma. To determine the importance of ganglion cell complex gcc analysis as a parameter for early diagnosis of glaucoma and for. The bestcorrected visual acuities were 1010 in both eyes. Having an early diagnosis is decisive, but usually patients present to the ophthalmologist when their visual acuity starts to decrease and the visual field defect. Utility of ganglion cell complex analysis in early diagnosis and.
Ganglion cell definition of ganglion cell by medical. Figure 1 ganglion cell complex gcc analysis and segmentation. Macular ganglion cell complex thinning in children with. A 55yearold man was admitted with a 2year history of pseudoexfoliation glaucoma. Each type encodes distinct visual features in parallel for transmission to the brain. Research article repeatability of perimacular ganglion cell complex analysis with spectraldomain optical coherence tomography dorothys. Optical coherence tomography and optic nerve edema. Repeatability of perimacular ganglion cell complex. In evolving cases of optic disc edema, oct of the rnfl can thus be an objective measurement of nerve swelling. The content of this book presents the viewpoint of the author and do not necessarily reflect. Retinal nerve fiber layer analysis, macular thickness assessment and ganglion cell complex measurements are instrumental in the diagnosis and evaluation of the condition. Macular thickness analysis for glaucoma diagnosis and.
The most important step in glaucoma management is probably the one of the diagnosis. The ganglion cell complex as an useful tool in glaucoma. Ganglion cell complex analysis in glaucoma patients. The avanti offers widefield 12mm scans, combined with en face oct, providing multilayered assessment of peripheral pathologies.
These existing clinical instruments concentrate on measuring the axons of the retinal ganglion cells adjacent to and on the optic nerve head. Psychology in your life chapter 5 terms from the book 31 terms. Glaucoma is defined as an optic neuropathy that alters the ganglion cells and all their segments. The rgcs begin in the inner plexiform layer ipl, the layer formed by the dendrites of the rgcs. Optical coherence tomography provides clinicians a novel way of measuring axon loss in patients with ms. Ganglion cell analysis detects early neurodegenerative disease.
However, retinal ganglion cells are large and complex cells extending from the inner retina all the way to the lateral geniculate nucleus lgn in the midbrain. It is well known that glaucoma is a multifactorial, progressive optic neuropathy characterized by the loss of retinal ganglion cells. The functional diversity of retinal ganglion cells in the. A retinal ganglion cell is a type of neuron located near the inner surface of the retina of the eye. A thickness map, automatically calculated using rtvue fourierdomain optical coherence tomography fdoct. Retina amacrine cells, particularly narrow field cells, are important for creating functional subunits within the ganglion cell layer and making it so that ganglion cells can observe a small dot. Macular ganglion cell analysis gca of the cirrus hdoct. The inset dotted square depicts the three anatomical layers included in the gcc analysis. Homonymous hemiatrophy of ganglion cell layer from. Two hundred eyes including 68 normal eyes, 70 eyes.
Role of ganglion cell complex gcc in evaluation of glaucoma. Role of optical coherence tomography in the evaluation and. Retinal ganglion cell rgc structure and function were followed with spectral domain optical. Glaucoma physician widefield oct improves glaucoma. The retinal nerve fiber layer nfl made up of the ganglion cell axons, the ganglion cell layer gcl made up of the ganglion cell bodies. Their perikarya are the largest of any retinal neurons and are located along the inner margin of the retina, in the ganglion cell layer. Retinal ganglion cells rgcs are large, complex cells. Subsequently, they extend from the inner retina and travel all the way to the. Ganglion cells peak density ranges between 31,600 and 37,800 cells mm,2 and the highest cells density in a horizontally oriented elliptical ring of 0. To study the relationship between macular ganglion cell complex gcc thickness and visual field defects vfd caused by central nervous system cns lesions in children and evaluate the. In the vertebrate visual system, all output of the retina is carried by retinal ganglion cells. Ganglion cell complex analysis as a potential indicator of. Cheung 1,2,3 singapore eye research institute, singapore national eye centre, singapore.
Ganglion cell complex analysis as a potential indicator of early neuronal loss in idiopathic intracranial hypertension geetha athappilly the new england eye center, tufts medical center, boston, massachusetts, usa. Glaucoma today the ganglion cell complex march 2011. Here they synapse with the bipolar and amacrine cells of the middle retina. In kaplanmeier analysis, survival curves showed the focal loss volume in the ganglion cell complex was highly predictive at 6 years, huang said. Ganglion cells begin at the inner plexiform layer ipl where they synapse with the bipolar and amacrine cells of the middle retina. With the advent of ganglion cell analysis gca looking at the ganglion cell complex gcc, weve opened up a new pathway to look beyond the eye itself and. Her edited version of the legendary book parsons diseases of the eye is very. Macular thickness analysis for glaucoma diagnosis and management. Rnfl, ganglion cell complex, and ganglion celleinner plexiform layer gcipl. Octgcc more sensitive at detecting chiasmal compression. Repeatability of perimacular ganglion cell complex analysis with spectraldomain optical coherence tomography. It receives visual information from photoreceptors via two intermediate neuron types. Macular thickness is a highly reproducible measurement on sdoct with intravisit and intervisit coefficients of variation of ganglion cellipl gcipl, also show good reproducibility. Pdf ganglion cell complex analysis in glaucoma patients.
B crosssectional fdoct bscan with segmentation of the gcc. Listing a study does not mean it has been evaluated by the u. Open access full text article ganglion cell complex. Ng, 1, 2 preeti gupta, 1, 2 yih chung tham, 1, 2 chye fong peck, 1 tien yin wong, 1, 2, 3 mohammad kamran ikram, 1, 3 and carol y. By analyzing the ganglion cell complex, oct can now help detect early axonal damage in optic nerve disease, even when the rnfl is edematous, and may be helpful in predicting visual outcomes. The term is also sometimes used to refer specifically to. Early axonal damage detection by ganglion cell complex. To investigate the ability of ganglion cell complex gcc analysis by optical coherence tomography oct to detect early axonal damage in nonarteritic anterior ischaemic optic neuropathy. Having an early diagnosis is decisive, but usually patients present to the ophthalmologist when their visual acuity starts to decrease and the visual field defect appears. The rt vue also provides similar analysis for ganglion cell complex thickness.
973 1053 1365 573 452 178 522 1166 1193 528 364 757 1136 722 686 937 978 514 771 1418 1503 793 692 974 12 1205 36 956 1133 1442 1215 351 451 290 388 554 1251